What is Major Depressive Disorder?

Major Depressive Disorder (MDD) is a serious,
biologically-based disorder:

It is prevalent and debilitating, and can be chronic and life-threatening —in fact, it is the leading cause of suicide in the United States.

MDD is characterized by:

MDD is common and disabling:

unmet needs

key facts

Results of the Sequenced Treatment Alternatives to Relieve Depression, or STAR*D trial, funded by the National Institute of Mental Health, indicated that:

two thirds two thirds

Nearly two-thirds of diagnosed and treated patients did not achieve remission with first line therapy.

Nearly two-thirds of diagnosed and treated patients did not achieve remission with first line therapy.

The majority of these initial failures also fail second line treatment

19.4 million

adults in the U.S.
had at least one major depressive episode
in 2019

12.8 million

adults received treatment for depression in the past year*

63.2%

of adults experienced failure with 1st line therapy in a large study†

69.4%

of adults experienced failure with 2nd line therapy in a large study†

*Treatment=seeing or talking to a health professional or other professional or using prescription medication for depression in the past year
†Based on the STAR*D study which included patients with major depressive disorder who received one (N=3,671) to four (N=123) successive acute treatment steps.
Those not achieving remission with or unable to tolerate a treatment step were encouraged to move to the next step. The first-level treatment was an antidepressant.
The primary endpoint was remission defined as QIDS-SR16 score ≤5 at exit from the indicated treatment step.